Sleep Genes

Brunner JI, Gotter AL, Millstein J, Garson S, Binns J, Fox SV, Savitz AT, Yang HS, Fitzpatrick K, Zhou L, Owens JR, Webber AL, Vitaterna MH, Kasarskis A, Uebele VN, Turek F, Renger JJ & Winrow CJ. 2011. Pharmacological validation of candidate causal sleep genes identified in an n2 cross. J Neurogenet, 25(4):167-81.

Yang HS, Shimomura K, Vitaterna MH & Turek FW. 2011. High-resolution mapping of a novel genetic locus regulating voluntary physical activity in mice. Genes Brain Behav. (Epub ahead of print)

Millstein J, Winrow CJ, Kasarskis A, Owens JR, Zhou L, Summa KC, Fitzpatrick K, Zhang B, Vitaterna MH, Schadt EE, Renger JJ & Turek FW. 2011. Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake. Sleep, 34(11):1469-77.

Winrow CJ, Williams DL, Kasarskis A, Millstein J, Laposky AD, Yang HS, Mrazek K, Zhou L, Owens JR, Radzicki D, Preuss F, Schadt EE, Shimomura K, Vitaterna MH, Zhang C, Koblan KS, Renger JJ & Turek FW. 2009. Uncovering the genetic landscape for multiple sleep-wake traits. PLoS One, 4(4):e5161.

Pitman JL, McGill JJ, Keegan KP & Allada R. 2006. A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature, 441(7094):753-6.


Clock Genes

Lim C, Lee J, Choi C, Kilman VL, Kim J, Park SM, Jang SK, Allada R & Choe J. 2011. The novel gene twenty-four defines a critical translational step in the Drosophila clock. Nature, 470(7334):399-403.

Shimomura K, Lowrey PL, Vitaterna MH, Buhr ED, Kumar V, Hanna P, Omura C, Izumo M, Low SS, Barrett RK, LaRue SI, Green CB & Takahashi JS. 2010. Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway. PNAS. 107(18):8399-403.

Kula-Eversole E, Nagoshi E, Shang Y, Rodriguez J, Allada R & Rosbash M. 2010. Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. PNAS, 107(30):13497-502.

Zhang L, Chung BY, Lear BC, Kilman VL, Liu Y, Mahesh G, Meissner RA, Hardin PE & Allada R. 2010. DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila. Curr Biol, 20(7):591-9.

Pfeiffenberger C, Lear BC, Keegan KP & Allada R. 2010. Processing Sleep Data Created with the Drosophila Activity Monitoring (DAM) System. Cold Spring Harb Protoc, 2010(11).

Lim C, Chung BY, Pitman JL, McGill JJ, Pradhan S, Lee J, Keegan KP, Choe J & Allada R. 2007. Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol, 17(12):1082-9.

Vitaterna MH, Ko CH, Chang AM, Buhr ED, Fruechte EM, Schook A, Antoch MP, Turek FW & Takahashi JS. 2006.The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. PNAS, 103(24):9327-32.

Lear BC, Lin JM, Keath JR, McGill JJ, Raman IM & Allada R. 2005. The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker. Neuron, 48(6):965-76.

Lear BC, Merrill CE, Lin JM, Schroeder A, Zhang L & Allada R. 2005. A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior. Neuron, 48(2):221-7.

Lin JM, Kilman VL, Keegan K, Paddock B, Emery-Le M, Rosbash M & Allada R. 2002. A role for casein kinase 2alpha in the Drosophila circadian clock. Nature, 420(6917):816-20.

King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW & Takahashi JS. 1997. Positional cloning of the mouse circadian clock gene. Cell, 89(4):641-53.

Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW & Takahashi JS. 1994. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science, 264(5159):719-25.




Circadian/Sleep/Metabolism Interactions

Arble DM, Vitaterna MH & Turek FW. 2011. Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. PLoS One, 6(9):e25079.

Bass J & Takahashi JS. 2010. Circadian integration of metabolism and energetics. Science, 330(6009):1349-54.

Arble DM, Ramsey KM, Bass J & Turek FW. 2010. Circadian disruption and metabolic disease: Findings from animal models. Best Pract Res Clin Endocrinol Metab, 24(5):785-800.

Bass J. 2010. High glucose, no cry. Nat Med, 16(10):1074-6.

Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS & Bass J. 2010. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature, 466(7306):627-31.

Su H, Marcheva B, Meng S, Liang FA, Kohsaka A, Kobayashi Y, Xu AW, Bass J & Wang X. 2010. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol, 339(1):38-50.

Arble DM, Bass J, Laposky AD, Vitaterna MH & Turek FW. 2009. Circadian timing of food intake contributes to weight gain. Obesity, 17(11):2100-2.

Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S & Bass J. 2009. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science, 324(5927):651-4.

Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, Kobayashi Y, Turek FW, Bass J. 2007. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab, 6(5):414-21.


Sleep/Circadian Disruption & Health

Summa KC, Vitaterna MH & Turek FW. 2012. Environmental perturbation of the circadian clock disrupts pregnancy in the mouse. PLoS ONE, 7(5):e37668.

Swanson G, Forsyth CB, Tang Y, Shaikh M, Zhang L, Turek FW & Keshavarzian A. 2011. Role of intestinal circadian genes in alcohol-induced gut leakiness. Alcohol Clin Exp Res, 35(7):1305-14.

Zee PC. 2010. Shedding light on the effectiveness of melatonin for circadian rhythm sleep disorders. Sleep, 33(12):1581-2.

Dodson ER, Zee PC. 2010. Therapeutics for circadian rhythm sleep disorders. Sleep Med Clin, 5(4):701-15.

Goldstein C & Zee PC. 2010. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med, 182(10):1332.

Reid KJ, Baron KG, Lu B, Naylor E, Wolfe L & Zee PC. 2010. Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia. Sleep Med, 11(9):934-40.

Zee PC & Goldstein CA. 2010. Treatment of shift work disorder and jet lag. Curr Treat Options Neurol, 12(5):396-411.

Westerberg CE, Lundgren EM, Florczak SM, Mesulam MM, Weintraub S, Zee PC & Paller KA. 2010. Sleep influences the severity of memory disruption in amnestic mild cognitive impairment: Results from sleep self-assessment and continuous activity monitoring. Alzheimer Dis Assoc Disord. (Epub ahead of print)

Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS & Bass J. 2005. Obesity and metabolic syndrome in circadian Clock mutant mice. Science, 308(5724):1043-5.







Column Three

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Phasellus rutrum elementum augue. Morbi ultrices libero sit amet tortor. Mauris semper tempor mi. Mauris eget ante quis nunc semper porta. Phasellus sodales auctor dui. Praesent laoreet vehicula leo. Nam porttitor, pede quis egestas auctor, libero orci ultrices nibh, elementum sodales sapien leo in odio.