The Center for Circadian Biology and Medicine
integrates both basic and clinical research into a unified program that has
as its goals:
1. To elucidate the fundamental mechanisms that underlie the
entrainment, generation and expression of circadian rhythms.
2. To determine the consequences of circadian rhythm dysfunctions
for human health, safety, performance and productivity.
3. To develop treatments to alleviate the adverse effects
of circadian rhythm dysfunctions, particularly circadian abnormalities associated
with advanced age.
To achieve these goals, four parallel but interactive lines
of research are carried out in the Center.
1. Cellular and molecular studies are performed using isolated
tissue and cells from circadian pacemakers in vertebrates to discover clock
2. Genetic approaches are utilized to isolate,
identify and characterize circadian clock mutants with the ultimate goal
of being able to clone clock-related genes and to identify the function
of their products.
3. Animal studies are performed using rodents
to study the physiological control of biological rhythms.
4. Human studies are focused on circadian
rhythms in both normal subjects and individuals with impaired health that
have (or may have) associated sleep and rhythm disorders.